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08-Feb-2017 19:56

Because the neural tube gives rise to the brain and spinal cord any mutations at this stage in development can lead to lethal deformities like anencephaly or lifelong disabilities like spina bifida.During this time, the walls of the neural tube contain neural stem cells, which drive brain growth as they divide many times.Once the neurons have reached their regional positions, they extend axons and dendrites, which allow them to communicate with other neurons via synapses.Synaptic communication between neurons leads to the establishment of functional neural circuits that mediate sensory and motor processing, and underlie behavior.

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These include differentiation, migration and axon guidance to their initial target areas.This review describes some of the mechanisms that regulate patterning and differentiation of the embryonic brain, which are implicated in neurogenesis of serotonergic neurons.It also covers the development of serotonergic axon pathways and the potential role of serotonin in regulating developmental processes.Gradually some of the cells stop dividing and differentiate into neurons and glial cells, which are the main cellular components of the CNS.

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The newly generated neurons migrate to different parts of the developing brain to self-organize into different brain structures.

Defects in neural development can lead to malformations and a wide variety of sensory, motor, and cognitive impairments, including holoprosencephaly and other neurological disorders such as Rett syndrome, Down syndrome and intellectual disability.



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